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Pure Ketamine Crystal Type R is a dissociative anesthetic that has been used in medical settings for decades. Ketamine exists as two mirror-image molecules known as enantiomers: R-ketamine (arketamine) and S-ketamine (esketamine). These two forms share similar chemical structures but may produce slightly different pharmacological effects. While S-ketamine is used in certain approved prescription treatments, including Spravato, researchers continue to investigate R-ketamine for its potential clinical advantages.

R-ketamine shows greater potency and longer-lasting antidepressant effects than S-ketamine in the social defeat stress model.